Cyproterone Acetate – an anti-androgen that combats DHT


Let’s see together the potential of Cyproterone Acetate, antiandrogenic steroid hormone possible ally for our hair.
Cyproterone Acetate, steroidal hormone antiandrogenic, may be able to reduce hair loss due to its anti-gonadotropic and progestative functionality..

It may inhibit androgenic hormone function, stopping the action of testosterone and dihydrotestosterone (DHT).

The male hormone par excellence, the active phase of testosterone, or DHT, is considered to be one of the most common causes of hair loss and thinning. It acts on the follicular cycle, weakening the follicles more and more until they fall out permanently.

Testosterone is produced in the Leydig cells of the male reproductive system by the action of luteinizing hormone (LH) released by the anterior pituitary gland. It is not a simple production process but, indeed, quite complex.


How does it act to counteract DHT?

One of the ways in which it acts is, first of all, already at the level of the anterior lobe of the pituitary gland, namely the adenohypophysis. At this point the cyproterone acetate causes an arrest, greatly decreasing the production of the luteinizing hormone LH. The latter promotes the production of androgens by stimulating men and women respectively at the cellular level in the reproductive system (male testicles or female ovaries).

When the LH values are low, the testosterone and dihydrotestosterone (DHT) values are also low. Considering also the additional antagonizing effect of cyproterone on the enzyme 5alpha-reductase, which converts testosterone into DHT, they will then be further reduced.

Another way in which cyproterone manages to combat the negative effects of DHT on the follicular cycle involves cytosolic receptors.

Cyproterone acetate behaves as a kind of anti-androgen receptor; this is because, by affinity, it entersinto competition with DHT for the same intracytoplasmic receptors, trying to block its passage into the cell nucleus.


Ciproterone acetate – oral or topical treatment?

It should be said from the outset that for the male sex, the treatment can only be carried out topically and with specific doses. Acting on the quantitative increase of sterorides could, in fact, also cause undesirable effects due to its progestinic action. This therapy is widely used to combat the androgenic alopecia in women, in which, however, there are no contraindications even in the case of oral administration.

Generally, topical products based on cyproterone at 0.5-1%, also include a percentage of progesterone at 1-2%. This combination would be able to completely halt metabolism and, along with it, the negative effects of testosterone (and DHT) on hair follicles.

The effectiveness of cyproterone acetate in the cure of baldness has been repeatedly proven over time after constant studies and trials in this regard. Performing a trichogram (microscopic examination to analyze the health of the hair) can be absolutely a good choice to be able to monitor over time the reduction of thinning thanks to ciproterone.

Clinical research in the field is constantly evolving, but we can certainly affirm the effectiveness of this hormone. In time there will certainly be new scientific discoveries for the treatment ofbaldness but, to date, ciproterone is strongly valid to counteract DHT


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