Hair disorders, such as alopecia, have a significant social and psychological influence. This is especially true for those who have lost their hair due to severe burns. Hair follicles are essential for proper wound healing and help prevent scar formation. Research in this field is crucial to help the many patients with alopecia problems.
Research on Hair Growth
There are intensive studies on hair growth and hair disorders. Research on follicular units is not yet complete, and doing research on human fetal material is often subject to restrictions. As a result, many studies are based on animals, although it is recognized that there are significant differences between animal and human skin. Results obtained from animal models are useful, but it is necessary to obtain results on human models for more effective treatments.
Study of the Mechanisms of Follicular Units
It is critical to discover and define the mechanisms underlying the formation of follicular units within human fetal skin. It is important to determine how progenitor cells are formed and how hair is subsequently formed within the follicular unit. These studies have shown that it is possible to organize organs into models that mimic embryos and utilize morphogenesis, proteins, and the extracellular matrix. Understanding cellular proteins is crucial to understanding epithelial tissues, including skin appendages.
HASCI Research on Follicular Unit Genetics
Hasci evaluated the potential of the molecular growth process to apply this knowledge to the creation of an in vitro model in humans. Human hair follicle development occurs during embryogenesis in the second trimester of gestation. This process is an interaction that depends on a variety of biochemical forms and results in the differentiation of the different components of the follicular unit.
HASCI Studies on Human and Animal Embryos
Despite progress, the application of cell therapies to hair loss has not progressed as hoped, probably because of the lack of knowledge about the mechanisms of human organogenesis. The lack of adequate studies on the human embryo hinders research. Most studies have focused on biomolecular aspects rather than the neurogenesis of the follicular unit. It is important to describe the cellular and molecular morphological stages of the human fetus and focus on the influence that the extracellular matrix has on the growth of the follicular unit.
Advanced Technologies of the Hair Science Institute
Current knowledge of follicular unit development in the human fetus can be complemented by techniques that mimic molecular cell production in follicular unit neurogenesis in vivo. Hasci based his research on follicular unit reproduction via an in vivo cloning and capillary restoration technique of hair stem cell transplantation. This approach represents an important step forward in research and understanding the evolution of follicular units in the human fetus.