Prostaglandin PGD2 and baldness – a follicle killer

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The negative role of prostaglandin PGD2 in hair health

Some recent clinical research has shown the interaction that exists between prostaglandins and hair follicular cycle.

Let’s see what effects the different types of prostaglandins can cause.

Prostaglandins – function and role in the inflammatory process

Prostaglandins are cyclopentanoic acids derived from arachidonic acidco, involved in numerous biological activities..

They behave in a manner similar to hormones, in that they are released from organs into the bloodstream as needed, going to act directly on the recipient organ. They are involved in inflammatory processes and perform their function in the very organ in which they are released.

They are named after the area in which they were discovered. They were first found in seminal fluid, developing the false belief that they were normally released only from a male gland, the prostate. Subsequently, research in this area was intensified, discovering that they are also produced in other parts of the body and defining their individual roles.

 

How many types of prostaglandins are there?

Although they have structural elements in common, there are different varieties of prostaglandins, differentiated in terms of chemical bonds (elements that bind on the cyclo-pentane ring and double bonds on the side chain). The types of prostaglandins produced by the body are identified by the abbreviation “PG” (which stands for Prostaglandins) followed by a capital letter from A to I as follows: PGA, PGB, PGC, PGD, PGE, PGF, PGG, PGH, and PGI.

Specifically, some clinical studies have analyzed the correlation between the different types of prostaglandins and thehair follicular cycle. 

What has emerged is that those belonging to the categories E and F (PGE and PGF) are able to promote hair growth. .

Those belonging to category D, on the contrary, can cause the advancement of calvices, blocking the phase of follicular maturation and, consequently, the process of hair growth.

 

The prostaglandin PGD2 – how it acts on baldness

The prostaglandin PGD2 acts on the stem cells of the hair follicles in the Bulge area, binding through the Gpr44 receptor. Those very cells act, in fact, on the hair life cycle and thus also of thehair. It can cause the miniaturization and the inhibition of the process of development of the hair follicle, leading the hair to become weaker and weaker and, eventually, to fall out.

Like the male hormones, DHT and testosterone, the prostaglandin PGD2 can be a real follicle killer.

At the University of Pennsylvania, some scholars conducted research on some guinea pigs to analyze the importance of the role of prostaglandin PGD2. In the course of the research, a biopsy was carried out on hairless areas, discovering that these possessed very high values of the prostaglandin mentioned. Nearby areas, however, where hair had not been affected, maintained normal levels of PGD2.

From this study it is particularly evident the responsibility that covers the prostaglandin PGD2 in the phenomenon of calvizie.

Also on the subject of hair transplantation, tests have shown what has been said: even in that case, theprostaglandin PGD2 can cause serious effects of hair miniaturization and follicularatrophization.

 

Latest research updates on prostaglandins

From the world of research, a molecule is currently in the process of being found that is able to inhibit PGD2 and create a binding to the Gpr44 receptor. Such binding could block the interaction with prostaglandin and, consequently, its negative effects on health hair.

The latest updates claim that stem cells are able to inhibit the action of the enzyme that causes the formation of PGD2 molecules. At this time are still being carried out in experiments on the subject, so we will still have to wait to get real pharmaceuticals designed against the fall and prostaglandin PGD2. Perhaps, these researches can finally find the solution to the process of follicular atrophy and promote thewell-being of hair.

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