Prostamol. Supplement based on Serenoa repens.
Prostamol is a supplement developed by the Italian pharmaceutical company Menarini. Made with an oily extract of Serenoa Repens Serenoa Repens with high fatty acid titration (88%), it was originally created to relieve the symptoms of BPH, benign prostatic hypertrophy.
As indicated in our article on Serenoa, the standardization (titration) of Prostamol is within the range useful to be considered a valid supplement of this substance.
Currently it is much publicized as a remedy for alopecia androgenetica, ie the common baldness.
Let us analyze below the characteristics of this hair loss and the ways in which Prostamol intervenes to slow down its course.
The androgenetic alopecia is the leading cause of hair loss. It affects more than 80% of men and 40% of women worldwide, which is why it is called “common baldness”.
Hair loss is caused by the action of androgenic hormones on the hair follicles of genetically predisposed individuals.
In particular, the DHT (Dihydrotestosterone), developed by the intervention of type 2 of an enzyme called 5-alpha-reductase on testosterone, attacks the hair follicles, causing a process called “miniaturization”. Hair appears thinner and more depigmented, and the growth process slows to a halt. This happens because the growth phase of the follicle (anagen phase) is reduced, and consequently the involution phase (catagen phase) and resting phase (telogen) are lengthened.
The action of DHT spares the hair follicles present in the occipital and parietal areas of the scalp. Hence the characteristic “crown” shape of the hair of baldness sufferers.
Prostamol is a supplement based on Serenoa Repens.
Serenoa Repens, also known as Saw palmetto, is a dwarf palm tree typical of the southeastern coast of the United States of America. The interesting element in the eyes of those suffering from baldness is its berry, a red/purple fruit, similar to an olive, which has healing properties.
In the last years, thanks to targeted advertising, the product is experiencing a great diffusion as a natural anti-DHT. Some claim that this plant can replace Finasteride in the treatment of androgenetic alopecia. We will discuss this aspect in the
For centuries, Native Americans have used Serenoa Repens to treat urinary tract infections and prostate inflammation.
The plant’s active ingredients are phytosterols (β-sitosterol, β-sitosterol-3-O-glucoside, campestrol, stigmasterol) and free fatty acids (oleic, myristic, lauric, linolenic, linoleic, palmitic acids).
How does Prostamol work?
Prostamol acts as Permixon, a prescription-only product. The fatty acid titration of the product is 88%.
It was only at the end of the last century that real scientific studies were conducted to understand the mode of action of Serenoa Repens and its effectiveness.
In 1988, in the study “The effect of Permixon on androgen receptors”, it was shown that Permixon is able to reduce the absorption of DHT by 40%. It should be pointed out that Finasteride is up to 70%.
Ten years later, the study “Effects of long-term treatment with Serenoa Repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia” confirmed the inhibition of the 5-alpha-reductase enzyme by Serenoa Repens.
The fatty acids of Serenoa Repens counteract the production of DHT by inhibiting the enzymes responsible for its production from testosterone and prevent DHT from binding to the receptors of the hair follicle. In this way, the DHT formed is not able to carry out its harmful function on the follicles.
Saw Palmetto also boasts an anti-inflammatory function, as it has been shown to inhibit the production of prostaglandins.
Posology and side effects of Prostamol
Experts recommend taking 320 mg daily on a full stomach. The time of day does not matter, as long as you wait 24 hours between one intake and the next.
Side effects are limited compared to those of other benign prostatic hyperplasia and baldness medications. A low percentage of people complain about episodes of nausea.
Avoid taking during pregnancy and lactation.
Can Prostamol Replace Finasteride?
As already mentioned, studies have shown that Serenoa Repens is able to improve the hair condition of individuals who undergo a systematic intake.
Specifically, a study published in November 2012 in the International Journal of Immunopathology and Pharmacology, entitled “Comparative effectiveness of Finasteride vs. Serenoa Repens in male androgenetic alopecia: a two-year study”, demonstrated a greater effectiveness of Finasteride vs. Serenoa Repens in the treatment of androgenetic alopecia.
The study involved 100 individuals suffering from common baldness, divided into two groups. The first group was given 1 mg of Finasteride per day, while the second group was given 320 mg of Serenoa Repens per day. Over a period of 2 years, photographs were taken monthly of all subjects.
In the group taking Finasteride, an increase in density was noted in 68% of individuals, compared to 38% in the group taking Serenoa Repens.
Furthermore, Finasteride was shown to act in the front, mid-scalp and vertex area, in contrast Serenoa Repens only in the vertex.
In conclusion, certainly Prostamol, and more generally Serenoa Repens, can be considered a valid approach to androgenetic alopecia. However, the effects cannot be considered in the same way as those obtained with Finasteride.
Other Serenoa Repens supplements. Alternatives to Prostamol
Serenoa Repens-based supplements include:
- Vitaminity Serenoa repens Extract
- Piping Rock Saw Palmetto