Topical Finasteride (2.5% gel) – H&W Data on Preparation of Parati Pharmacy

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finasteride gel 2,5%

What is Topical Finasteride (2.5% gel) ?
For more than 20 years, finasteride, marketed as Propecia or in generic form, has been considered one of the cornerstones for the treatment of androgenetic-type baldness.

Unfortunately, however, over the years, studies have increased showing that the drug can have side effects, even permanent ones, on the sexual sphere in particular, and there has been talk of a post-finasteride syndrome.

Less than 2 years ago we published a study by a renowned urologist presented at the ISHRS conference in Chicago and which you can view here:

http://bellicapelli.forumfree.it/?t=72788544

This combination of factors has led many patients to begin to question the use of oral finasteride as part of a treatment aimed at stabilizing baldness.

Although there is no doubt about the effectiveness of oral finasteride in the treatment of androgenetic alopecia few patients seem to be willing to take the risk of a less satisfying sex life because of erection problems or significantly reduced libido.

 

Data from Hasson&Wong show that in 2010, half of the patients contacting the clinic were following treatment with Propecia or Proscar. This percentage was drastically reduced in 2015, out of 500 patients operated on only 18% were following a treatment with finasteride.

The question then arose as to whether there was a possibility of using finasteride in topical form on the scalp so as to avoid side effects.

Finasteride is a lipophilic substance (i.e., it dissolves easily in oils and fats) and can be absorbed quickly through the scalp if mixed with other substances such as solvents and/or agents that enhance its penetration.

The problem is not efficacy but the fact that until now there was no way to ensure that the substance did not pass from the scalp into the bloodstream thus producing a “systemic” effect.

Although the incidence of side effects was undoubtedly lower with topical use than with oral administration there was no doubt that undesirable effects could still occur.

In recent years, however, new techniques for transcutaneous absorption of active ingredients have been developed aimed at trying to “block” them at the level of the scalp while avoiding systemic absorption.

 

The study of these techniques requires large investments in technology and specific expertise, which is why the Hasson&Wong Clinic decided to establish a collaboration with an echogeutic laboratory specializing in transcutaneous drug delivery systems and the University of Milan to develop a 2.5% Finasteride topical gel.

The study group covers about 300 patients the efficacy seems to be quite similar to that of finasteride with a blood absorption level of 1/18th that of oral finasteride. So far no sexual side effects have been reported in any of the patients who are using 2.5% finasteride gel, and it should be noted that some of these patients had experienced serious problems using Propecia or Proscar.

 

The University of Milan has carried out studies on permeation of the substance (using Franz cells). The results are very encouraging and can be viewed at this link:

https://3pfizs243h34c09mn6s0ul69-wpengine.netdna-ssl.com/wp-content/uploads/2016/01/evaluation-finasteride-solution-DR-HASSON.pdf

Further studies are underway to verify the reduction of DHT in the blood and systemic absorption.

 

For those people who are frightened by the short- and long-term side effects of oral finasteride, topical gel may be a viable alternative.

The concern of some people is related to the fact that the gel has not been subjected to rigorous clinical trials as is done for any new drug. It should be emphasized, however, that we are not talking about a new substance but simply a new method of delivering it, and therefore it is virtually impossible that there could be side effects that are more far-reaching or different from those that can occur with finasteride in oral form.

There are few large-scale studies on topical finasteride, one of which concerns the drug dynamics of the substance and can be viewed here:

https://3pfizs243h34c09mn6s0ul69-wpengine.netdna-ssl.com/wp-content/uploads/2016/03/p040-pharmacodynamic-of-p-3074-finateride-topical-solution.pdf

 

The only important warning is that related to pregnant women who should not come in contact directly or indirectly with topical finasteride gel.

Finasteride gel is not formulated to replace oral finasteride but only for those patients who have experienced side effects with Propecia and the like and are looking for an effective way to stop hair loss.

Among the possible problems with the use of the gel is in my opinion that of the cost, which is comparable to that of Propecia but is much higher than that of Proscar or generic 5 mg finasteride, and also that of the difficulty of application for those with long hair or a rather high density of natives.

The positive note is my opinion without a doubt the efficacy and also the fact that the product does not grease or soil the scalp.

Many users have asked for clarification on how to use it:

It is necessary to apply 1 ml of product (corresponding to 4 clicks of the blister pack or a dispensing depending on the package that is sent) on the scalp massaging for about 1 minute with the fingertips. The product should not be applied to the hair. It is preferable to apply it for example after showering and after drying the hair. It is possible to use it if you are using Minoxidil but it would be preferable to allow at least 1 hour between product applications.

Regarding efficacy, I am happy to share with you pictures of patients who have used finasteride gel and have achieved very significant results:

 

PATIENT 1

FIRST

AFTER 6 MONTHS OF USING FINASTERIDE GEL 2.5%

AFTER 1 YEAR OF USING FINASTERIDE GEL 2.5%

AFTER 2 YEARS OF USING FINASTERIDE GEL 2.5%

 

PATIENT 2 .

First

After 6 MONTHS OF USE OF FINASTERIDE GEL 2.5%

After 9 MONTHS OF USE OF FINASTERIDE GEL 2.5%

 

PATIENT 3 .

First

AFTER ONLY 2 MONTHS OF USE OF FINASTERIDE GEL

CONFRACTION PRE VS 2 MONTHS OF FINASTERIDE GEL 2.5%

PATIENT 4 – FINASTERIDE GEL ON THE CROWN FOR 7 MONTHS – PATIENT RECEIVED A TRANSPLANTATION IN THE HAIRLINE AND FRONTAL AREA

PATIENT 5 – BELLICAPEL CONTEGRILLI USER – FINA GEL FOR 1 MONTH NOT CONSTANTLY (TRAPPING ON FRONTAL) – RESULTS ON CROWN ONLY DUE TO FINASTERIDE GEL 2.5%

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