Biomimetic peptides – a cure for baldness

struttura peptidi
Let’s see what are the hair wellness benefits brought by Biomimetic Peptides, on all types of hair loss

Biomimetic Peptides can be considered a truly innovative discovery in the field of hair wellness.

What’s so special about them? Compared to the normal peptides that we commonly have in our bodies, they are created artificially in the laboratory.

They are composed of 7 peptides and small synthetic amino acid sequences, created to try to mimic the action of the natural proteins they resemble along with the same cellular interaction functions.

In cosmetic products they are used together with molecules of a lipophilic nature, or within liposomes. Several products designed for calvariety (care and prevention) contain, in fact, biomimetic peptides bound and conveyed with hyaluronic acid.


The Bio-mimetic Peptides already tested:

    • Oligopeptide-54 (CG-Nokkin) – Acts by blocking the action of the proteins that regulate follicular growth typical of Androgenic Alopecia, the BMP4s. Stops hair loss by preventing its depigmentation; moreover, it can improve and revive the scalp and hair follicles and, consequently, promote the growth of a healthy hair.
    • Decapeptide-25 (CG-Cheverin) – It manages to block the mechanism of action of the enzyme 5α-reductase, so as to reduce the amount of dihydrotestosterone (DHT). Produces activation of β-catenin to stimulate hair growth
    • Oligopeptide-41 (CG-Keramin1) – Inhibits the role of protein DKK1, the great enemy of hair follicles, and stops the process of apoptosis by oxidation by sunlight. It favors, in this way, the cellular increase and the hardening of the follicles.

Generally, vitamins and natural extracts can be combined with these peptides..

Examples include:

    • Serenoa Repens – fights DHT
    • Biotin
    • Retinol Palmitate
    • Ginkgo Biloba – scalp soothing and circulatory stimulant
    • Portulaca Oleracea – protective power against external factors harmful to the scalp
    • Polygala Tenuifolia Root – promotes hair growth and prevents hair loss
    • Thuja Orientalis – stops baldness and invigorates hair follicles

Biomimetic Peptides lend themselves to being incorporated into common cleansing products (e.g., shampoos) or to being used topically in specific scalp products or lotions.

Their potential is scientifically proven. Tests have been conducted on both female and male patients and on all types of baldness, except for scarring alopecia. The most important indication for satisfactory results remains, however, constancy. It is necessary to continue and repeat the treatment over time.


The most valid products

Over the years, research has led to the creation of valid products based on active ingredients with considerable effectiveness. Let’s see some of them:

    • Latanoprost – similar to Prostaglandin F2α: prostaglandins, a fundamental set of fatty acids present in our organism, seem to be involved in the management of the follicular growth cycle, favoring and prolonging the anagen phase for each follicle that is in telogen phase.
    • Capixyl® – consists of Acetyl Tetrapeptide-3, Dextran, Butylene Glycol and Trifolium Pratensis flower extract. Interacts with the 5α-reductase enzyme which moderates DHT values, promoting theanagen phase and counteracting hair miniaturization.
    • Minoxidil now widely used and known in hair care, it is capable of supporting bulbous structures by interacting with various potassium channels. It favors the longer duration of the anagen phase and, consequently, hair growth.

The galenic preparation of these products is not found ready-made in the market, but can be ordered in the pharmacy on the instructions of the attending physician. The active ingredients mentioned are not replaceable or interchangeable, as each of them has specific characteristics and functions.


Indications for topical treatment

During the topical treatment with these products it is possible to penetrate deeply (papilla and hair matrix) the active ingredient in two different ways:

    • Capillary/transfollicular – starting initially from the hair follicles to penetrate through the sebaceous glands
    • Transcutaneous – touching the different layers of the epidermis and the basal membrane

In order to obtain good results, the topical treatment must be practiced with constancy and following all the indications of the specialist; the treatment could also be associated to a pharmacological therapy.

One of the main advantages of this type of therapy is the targeted effectiveness: not involving the rest of the organism, it is able to act directly in the affected areas without attached side effects.

As we have seen, fighting calvariety is by no means easy. Various treatments should be evaluated in order to find the best possible solution for each individual case, always with the premise of turning to experts in the cure of calvices.


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